6YQK

Crystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a methylisoquinoline Fasudil-derivative (soaked)

6YQK の概要

• エントリーDOI: 10.2210/pdb6yqk/pdb
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 5-(1,4-diazepan-1-ylsulfonyl)-4-methyl-isoquinoline, ... (4 entities in total)
• 機能のキーワード: phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase
• 由来する生物種: Cricetulus griseus (Chinese hamster); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43492.46

構造登録者

Oebbeke, M.,Wienen-Schmidt, B.,Heine, A.,Klebe, G. (登録日: 2020-04-17, 公開日: 2020-10-14, 最終更新日: 2024-01-24)

• 主引用文献: Wienen-Schmidt, B.,Oebbeke, M.,Ngo, K.,Heine, A.,Klebe, G.; Two Methods, One Goal: Structural Differences between Cocrystallization and Crystal Soaking to Discover Ligand Binding Poses.; Chemmedchem, 16:292-300, 2021; PubMed: 33029876; DOI: 10.1002/cmdc.202000565

実験手法

X-RAY DIFFRACTION (1.67 Å)