6YPE

Crystal structure of the human neuronal pentraxin 1 (NP1) pentraxin (PTX) domain.

6YPE の概要

• エントリーDOI: 10.2210/pdb6ype/pdb
• 分子名称: Neuronal pentraxin-1, CALCIUM ION, CACODYLATE ION, ... (4 entities in total)
• 機能のキーワード: cell adhesion, synapse formation, ampa receptor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 45833.70

構造登録者

Elegheert, J.,Clayton, A.J.,Aricescu, A.R. (登録日: 2020-04-15, 公開日: 2020-06-03, 最終更新日: 2024-10-09)

主引用文献

Suzuki, K.,Elegheert, J.,Song, I.,Sasakura, H.,Senkov, O.,Matsuda, K.,Kakegawa, W.,Clayton, A.J.,Chang, V.T.,Ferrer-Ferrer, M.,Miura, E.,Kaushik, R.,Ikeno, M.,Morioka, Y.,Takeuchi, Y.,Shimada, T.,Otsuka, S.,Stoyanov, S.,Watanabe, M.,Takeuchi, K.,Dityatev, A.,Aricescu, A.R.,Yuzaki, M.
A synthetic synaptic organizer protein restores glutamatergic neuronal circuits.
Science, 369:-, 2020

PubMed Abstract: Neuronal synapses undergo structural and functional changes throughout life, which are essential for nervous system physiology. However, these changes may also perturb the excitatory-inhibitory neurotransmission balance and trigger neuropsychiatric and neurological disorders. Molecular tools to restore this balance are highly desirable. Here, we designed and characterized CPTX, a synthetic synaptic organizer combining structural elements from cerebellin-1 and neuronal pentraxin-1. CPTX can interact with presynaptic neurexins and postsynaptic AMPA-type ionotropic glutamate receptors and induced the formation of excitatory synapses both in vitro and in vivo. CPTX restored synaptic functions, motor coordination, spatial and contextual memories, and locomotion in mouse models for cerebellar ataxia, Alzheimer's disease, and spinal cord injury, respectively. Thus, CPTX represents a prototype for structure-guided biologics that can efficiently repair or remodel neuronal circuits.

PubMed: 32855309
DOI: 10.1126/science.abb4853

実験手法

X-RAY DIFFRACTION (1.45 Å)