6YPD
Crystal structure of AmpC from E. coli with Cyclic Boronate 3 (CB3 / APC308)
Summary for 6YPD
Entry DOI | 10.2210/pdb6ypd/pdb |
Descriptor | Beta-lactamase, (3~{S})-2,2-bis(oxidanyl)-3-(phenylmethylsulfanyl)-3,4-dihydro-1,2-benzoxaborinin-2-ium-8-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... (8 entities in total) |
Functional Keywords | beta lactamase, antibiotic resistance, bicyclic boronate, hydrolase |
Biological source | Escherichia coli K-12 |
Total number of polymer chains | 1 |
Total formula weight | 40434.46 |
Authors | Lang, P.A.,Brem, J.,Schofield, C.J. (deposition date: 2020-04-15, release date: 2020-06-24, Last modification date: 2024-01-24) |
Primary citation | Lang, P.A.,Parkova, A.,Leissing, T.M.,Calvopina, K.,Cain, R.,Krajnc, A.,Panduwawala, T.D.,Philippe, J.,Fishwick, C.W.G.,Trapencieris, P.,Page, M.G.P.,Schofield, C.J.,Brem, J. Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C beta-Lactamase from Escherichia coli . Biomolecules, 10:-, 2020 Cited by PubMed: 32545682DOI: 10.3390/biom10060899 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report