6YNK
Crystal structure of YTHDC1 with compound DHU_DC1_068
Summary for 6YNK
Entry DOI | 10.2210/pdb6ynk/pdb |
Descriptor | YTHDC1, 6-[[furan-2-ylmethyl(methyl)amino]methyl]-5~{H}-pyrimidine-2,4-dione, SULFATE ION, ... (5 entities in total) |
Functional Keywords | ythdc1, m6a, complex, inhibitor, rna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 43279.42 |
Authors | Bedi, R.K.,Huang, D.,Wiedmer, L.,Caflisch, A. (deposition date: 2020-04-13, release date: 2020-07-15, Last modification date: 2024-01-24) |
Primary citation | Li, Y.,Bedi, R.K.,Nai, F.,von Roten, V.,Dolbois, A.,Zalesak, F.,Nachawati, R.,Huang, D.,Caflisch, A. Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5:100057-, 2022 Cited by DOI: 10.1016/j.ejmcr.2022.100057PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
Download full validation report