6YM5

Crystal structure of BAY-091 with PIP4K2A

6YM5 の概要

• エントリーDOI: 10.2210/pdb6ym5/pdb
• 分子名称: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, PHOSPHATE ION, (2~{R})-2-[[3-cyano-2-[4-(2-fluoranyl-3-methyl-phenyl)phenyl]-1,7-naphthyridin-4-yl]amino]butanoic acid, ... (4 entities in total)
• 機能のキーワード: pip4k2a, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 91696.85

構造登録者

Holton, S.J.,Wortmann, L.,Braeuer, N.,Irlbacher, H.,Weiske, J.,Lechner, C.,Meier, R.,Puetter, V.,Christ, C.,ter Laak, T.,Lienau, P.,Lesche, R.,Nicke, B.,Bauser, M.,Haegebarth, A.,von Nussbaum, F.,Mumberg, D.,Lemos, C. (登録日: 2020-04-07, 公開日: 2021-04-14, 最終更新日: 2024-01-24)

• 主引用文献: Wortmann, L.,Brauer, N.,Holton, S.J.,Irlbacher, H.,Weiske, J.,Lechner, C.,Meier, R.,Karen, J.,Sioberg, C.B.,Putter, V.,Christ, C.D.,Ter Laak, A.,Lienau, P.,Lesche, R.,Nicke, B.,Cheung, S.H.,Bauser, M.,Haegebarth, A.,von Nussbaum, F.,Mumberg, D.,Lemos, C.; Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A.; J.Med.Chem., 64:15883-15911, 2021; PubMed: 34699202; DOI: 10.1021/acs.jmedchem.1c01245

実験手法

X-RAY DIFFRACTION (2.5 Å)