6YLT

Translation initiation factor 4E in complex with 3-MeBn7GpppG mRNA 5' cap analog

6YLT の概要

• エントリーDOI: 10.2210/pdb6ylt/pdb
• 分子名称: Eukaryotic translation initiation factor 4E, [[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-methylphenyl)methyl]-6-oxidanylidene-1~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate (3 entities in total)
• 機能のキーワード: cap analog, translation initiation factor, 3-mebn7gpppg, protein-ligand complex, eif4e, translation
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 92679.49

構造登録者

Kubacka, D.,Wojcik, R.,Baranowski, M.R.,Kowalska, J.,Jemielity, J. (登録日: 2020-04-07, 公開日: 2020-04-29, 最終更新日: 2024-01-24)

• 主引用文献: Wojcik, R.,Baranowski, M.R.,Markiewicz, L.,Kubacka, D.,Bednarczyk, M.,Baran, N.,Wojtczak, A.,Sikorski, P.J.,Zuberek, J.,Kowalska, J.,Jemielity, J.; Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5' cap Analogs: Synthesis and Evaluation as Modulators of Translation.; Pharmaceutics, 13:-, 2021; PubMed: 34834356; DOI: 10.3390/pharmaceutics13111941

実験手法

X-RAY DIFFRACTION (2.67 Å)