6YIN

Crystal structure of the first bromodomain of BRD4 in complex with a benzo-diazepine ligand

Summary for 6YIN

• Entry DOI: 10.2210/pdb6yin/pdb
• Descriptor: Bromodomain-containing protein 4, (4~{R})-~{N}-[3-(7-methoxy-3,4-dihydro-2~{H}-quinolin-1-yl)propyl]-4-methyl-2-oxidanylidene-1,3,4,5-tetrahydro-1,5-benzodiazepine-6-carboxamide (3 entities in total)
• Functional Keywords: bromodomain, brd4, small molecule, benzo-diazepine, sgc, structural genomics consortium, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15521.90

Authors

Picaud, S.,Brand, M.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Conway, S.,Filippakopoulos, P. (deposition date: 2020-04-01, release date: 2020-04-15, Last modification date: 2024-01-24)

• Primary citation: Picaud, S.,Brand, M.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Conway, S.,Filippakopoulos, P.; Crystal structure of the first bromodomain of BRD4 in complex with a benzo-diazepine ligand; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.53 Å)