6YHX
Solution NMR Structure of APP I45T mutant TMD
Summary for 6YHX
Entry DOI | 10.2210/pdb6yhx/pdb |
NMR Information | BMRB: 34510 |
Descriptor | Amyloid-beta precursor protein I45T mutant (1 entity in total) |
Functional Keywords | app, gamma secretase, transmembrane, membrane protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 3058.87 |
Authors | Silber, M.,Muhle-Goll, C. (deposition date: 2020-03-31, release date: 2020-12-09, Last modification date: 2024-05-15) |
Primary citation | Silber, M.,Hitzenberger, M.,Zacharias, M.,Muhle-Goll, C. Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11:4426-4433, 2020 Cited by PubMed: 33232115DOI: 10.1021/acschemneuro.0c00640 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report