6YH9

Crystal structure of chimeric carbonic anhydrase XII with 2,3,6-trifluoro-5-{[(1R,2S)-2-hydroxy-1,2-diphenylethyl]amino}-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide

6YH9 の概要

• エントリーDOI: 10.2210/pdb6yh9/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 2,3,6-trifluoro-5-{[(1R,2S)-2-hydroxy-1,2-diphenylethyl]amino}-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, ... (4 entities in total)
• 機能のキーワード: drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29816.83

構造登録者

Smirnov, A.,Manakova, E.,Grazulis, S. (登録日: 2020-03-28, 公開日: 2021-04-07, 最終更新日: 2024-01-24)

• 主引用文献: Smirnoviene, J.,Smirnov, A.,Zaksauskas, A.,Zubriene, A.,Petrauskas, V.,Mickeviciute, A.,Michailoviene, V.,Capkauskaite, E.,Manakova, E.,Grazulis, S.,Baranauskiene, L.,Chen, W.Y.,Ladbury, J.E.,Matulis, D.; Switching the Inhibitor-Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII.; Chemistryopen, 10:567-580, 2021; PubMed: 33945229; DOI: 10.1002/open.202100042

実験手法

X-RAY DIFFRACTION (1.55 Å)