6YF3

FKBP12 in complex with the BMP potentiator compound 10 at 1.00A resolution

6YF3 の概要

• エントリーDOI: 10.2210/pdb6yf3/pdb
• 関連するPDBエントリー: 6YF0 6YF1 6YF2
• 分子名称: Peptidyl-prolyl cis-trans isomerase FKBP1A, (1~{R},9~{S},12~{S},13~{R},14~{S},17~{R},18~{E},21~{S},23~{S},24~{R},25~{S},27~{R})-17-ethyl-25-methoxy-12-[(~{E})-1-[(1~{R},3~{R},4~{R})-3-methoxy-4-oxidanyl-cyclohexyl]prop-1-en-2-yl]-13,19,21,27-tetramethyl-1,14,23-tris(oxidanyl)-11,28-dioxa-4-azatricyclo[22.3.1.0^{4,9}]octacos-18-ene-2,3,10,16-tetrone, CADMIUM ION, ... (6 entities in total)
• 機能のキーワード: immunosuppression, immunosuppressant, bmp enhancer program, isomerase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12974.96

構造登録者

Kallen, J. (登録日: 2020-03-25, 公開日: 2021-03-10, 最終更新日: 2024-01-24)

• 主引用文献: Larraufie, M.H.,Gao, X.,Xia, X.,Devine, P.J.,Kallen, J.,Liu, D.,Michaud, G.,Harsch, A.,Savage, N.,Ding, J.,Tan, K.,Mihalic, M.,Roggo, S.,Canham, S.M.,Bushell, S.M.,Krastel, P.,Gao, J.,Izaac, A.,Altinoglu, E.,Lustenberger, P.,Salcius, M.,Harbinski, F.,Williams, E.T.,Zeng, L.,Loureiro, J.,Cong, F.,Fryer, C.J.,Klickstein, L.,Tallarico, J.A.,Jain, R.K.,Rothman, D.M.,Wang, S.; Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury.; Cell Chem Biol, 28:1271-, 2021; PubMed: 33894161; DOI: 10.1016/j.chembiol.2021.04.001

実験手法

X-RAY DIFFRACTION (1 Å)