6YEO

Crystal structure of AmpC from E. coli with cyclic boronate 2

6YEO の概要

• エントリーDOI: 10.2210/pdb6yeo/pdb
• 分子名称: Beta-lactamase, (4~{R})-4-[[4-(aminomethyl)phenyl]carbonylamino]-3,3-bis(oxidanyl)-2-oxa-3-boranuidabicyclo[4.4.0]deca-1(10),6,8-triene-10-carboxylic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (8 entities in total)
• 機能のキーワード: beta lactamase, antibiotic resistance, bicyclic boronate, hydrolase
• 由来する生物種: Escherichia coli (strain K12)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 161109.13

構造登録者

Lang, P.A.,Schofield, C.J.,Brem, J. (登録日: 2020-03-25, 公開日: 2020-06-24, 最終更新日: 2024-01-24)

• 主引用文献: Lang, P.A.,Parkova, A.,Leissing, T.M.,Calvopina, K.,Cain, R.,Krajnc, A.,Panduwawala, T.D.,Philippe, J.,Fishwick, C.W.G.,Trapencieris, P.,Page, M.G.P.,Schofield, C.J.,Brem, J.; Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C beta-Lactamase from Escherichia coli .; Biomolecules, 10:-, 2020; PubMed: 32545682; DOI: 10.3390/biom10060899

実験手法

X-RAY DIFFRACTION (2.037 Å)