6YD7

X-ray structure of furin in complex with the canavanine-based inhibitor 4-guanidinomethyl-phenylacetyl-Arg-Tle-Canavanine-Amba

Summary for 6YD7

Entry DOI	10.2210/pdb6yd7/pdb
Descriptor	Furin, 4-guanidinomethyl-phenylacetyl-Arg-Tle-Canavanine-Amba, CALCIUM ION, ... (8 entities in total)
Functional Keywords	protease, inhibitor, complex, canavanine, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	53371.96
Authors	Dahms, S.O. (deposition date: 2020-03-20, release date: 2021-02-17, Last modification date: 2024-01-31)
Primary citation	Lam van, T.V.,Heindl, M.R.,Schlutt, C.,Bottcher-Friebertshauser, E.,Bartenschlager, R.,Klebe, G.,Brandstetter, H.,Dahms, S.O.,Steinmetzer, T. The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin. Acs Med.Chem.Lett., 12:426-432, 2021 Cited by PubMed: 33732412 DOI: 10.1021/acsmedchemlett.0c00651 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation