6YAT

Crystal structure of STK4 (MST1) in complex with compound 6

Summary for 6YAT

Entry DOI	10.2210/pdb6yat/pdb
Descriptor	Serine/threonine-protein kinase 4, (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, GLYCEROL, ... (5 entities in total)
Functional Keywords	kinase, kinase inhibitor, mst1, stk4, hippo pathway, chemical probe, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	73135.32
Authors	Chaikuad, A.,Bata, N.,Limpert, A.S.,Lambert, L.J.,Bakas, N.A.,Cosford, N.D.P.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-03-13, release date: 2020-04-29, Last modification date: 2024-01-24)
Primary citation	Bata, N.,Chaikuad, A.,Bakas, N.A.,Limpert, A.S.,Lambert, L.J.,Sheffler, D.J.,Berger, L.M.,Liu, G.,Yuan, C.,Wang, L.,Peng, Y.,Dong, J.,Celeridad, M.,Layng, F.,Knapp, S.,Cosford, N.D.P. Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia. J.Med.Chem., 65:1352-1369, 2022 Cited by PubMed: 34807584 DOI: 10.1021/acs.jmedchem.1c00804 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.58 Å)

Structure validation