6Y9R
Crystal structure of GSK-3b in complex with the 1H-indazole-3-carboxamide inhibitor 2
Summary for 6Y9R
Entry DOI | 10.2210/pdb6y9r/pdb |
Descriptor | Glycogen synthase kinase-3 beta, ~{N}-[[1-(2-methoxyethyl)piperidin-4-yl]methyl]-5-(5-propan-2-yloxypyridin-3-yl)-1~{H}-indazole-3-carboxamide, ACETATE ION, ... (5 entities in total) |
Functional Keywords | glycogen synthase kinase-3 beta, indazole, inhibitor, kinase, transferase, proteros biostructures gmbh |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 40577.57 |
Authors | Krapp, S.,Griessner, A.,Blaesse, M.,Buonfiglio, R.,Ombrato, R. (deposition date: 2020-03-10, release date: 2020-05-20, Last modification date: 2020-07-08) |
Primary citation | Buonfiglio, R.,Prati, F.,Bischetti, M.,Cavarischia, C.,Furlotti, G.,Ombrato, R. Discovery of Novel Imidazopyridine GSK-3 beta Inhibitors Supported by Computational Approaches. Molecules, 25:-, 2020 Cited by PubMed: 32380735DOI: 10.3390/molecules25092163 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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