6Y8K
Crystal structure of CD137 in complex with the cyclic peptide BCY10916
This is a non-PDB format compatible entry.
Summary for 6Y8K
Entry DOI | 10.2210/pdb6y8k/pdb |
Descriptor | Tumor necrosis factor receptor superfamily member 9, BCY10916, ACETATE ION, ... (8 entities in total) |
Functional Keywords | tnfrsf9, cd137, 4-1bb, bicyclic peptide, bicycle, bcy10916, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 20206.67 |
Authors | Upadhyaya, P.,Kublin, J.,Dods, R.,Kristensson, J.,Lahdenranta, J.,Kleyman, M.,Repash, E.,Ma, J.,Mudd, G.,Van Rietschoten, K.,Haines, E.,Harrison, H.,Beswick, P.,Chen, L.,McDonnell, K.,Battula, S.,Hurov, K.,Keen, N. (deposition date: 2020-03-05, release date: 2021-02-03, Last modification date: 2024-01-24) |
Primary citation | Upadhyaya, P.,Lahdenranta, J.,Hurov, K.,Battula, S.,Dods, R.,Haines, E.,Kleyman, M.,Kristensson, J.,Kublin, J.,Lani, R.,Ma, J.,Mudd, G.,Repash, E.,Van Rietschoten, K.,Stephen, T.,You, F.,Harrison, H.,Chen, L.,McDonnell, K.,Brandish, P.,Keen, N. Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist. J Immunother Cancer, 9:-, 2021 Cited by PubMed: 33500260DOI: 10.1136/jitc-2020-001762 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.011 Å) |
Structure validation
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