6Y89

Crystal structure of the cAMP-dependent protein kinase A cocrystallized with Methyl 5-isoquinolinecarboxylate and PKI (5-24)

Summary for 6Y89

• Entry DOI: 10.2210/pdb6y89/pdb
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, methyl isoquinoline-5-carboxylate, ... (7 entities in total)
• Functional Keywords: phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase
• Biological source: Cricetulus griseus (Chinese hamster); More
• Total number of polymer chains: 2
• Total formula weight: 43866.00

Authors

Oebbeke, M.,Gerber, H.-D.,Heine, A.,Klebe, G. (deposition date: 2020-03-04, release date: 2021-03-31, Last modification date: 2024-01-24)

• Primary citation: Oebbeke, M.,Wienen-Schmidt, B.,Gerber, H.-D.,Heine, A.,Klebe, G.; Fragment based drug design - Small chemical changes of fragments effecting big changes in binding; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.56 Å)