6Y4T

Crystal structure of p38 in complex with SR63.

Summary for 6Y4T

Entry DOI	10.2210/pdb6y4t/pdb
Descriptor	Mitogen-activated protein kinase 14, 5-azanyl-~{N}-[[4-[[(2~{S})-1-[[(2~{S})-butan-2-yl]amino]-4-cyclohexyl-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	kinase, kinase inhibitor, mapk, mapk14, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Mus musculus (House mouse)
Total number of polymer chains	1
Total formula weight	42388.40
Authors	Chaikuad, A.,Roehm, S.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-02-23, release date: 2020-03-04, Last modification date: 2024-01-24)
Primary citation	Rohm, S.,Schroder, M.,Dwyer, J.E.,Widdowson, C.S.,Chaikuad, A.,Berger, B.T.,Joerger, A.C.,Kramer, A.,Harbig, J.,Dauch, D.,Kudolo, M.,Laufer, S.,Bagley, M.C.,Knapp, S. Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208:112721-112721, 2020 Cited by PubMed: 33035818 DOI: 10.1016/j.ejmech.2020.112721 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation