6XZK

Structure of zVDR LBD-Calcitriol in complex with chimera 13

Summary for 6XZK

• Entry DOI: 10.2210/pdb6xzk/pdb
• Descriptor: Vitamin D3 receptor A, GLU-ASN-ALA-UIA-URL-URY-URV-UZN-LYS, 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, ... (5 entities in total)
• Functional Keywords: nuclear receptor, foldamer, helix mimicry, protein-protein interaction, gene regulation
• Biological source: Danio rerio (Zebrafish); More
• Total number of polymer chains: 2
• Total formula weight: 35761.79

Authors

Buratto, J.,Belorusova, A.Y.,Rochel, N.,Guichard, G. (deposition date: 2020-02-04, release date: 2021-02-17, Last modification date: 2024-01-24)

• Primary citation: Cussol, L.,Mauran-Ambrosino, L.,Buratto, J.,Belorusova, A.Y.,Neuville, M.,Osz, J.,Fribourg, S.,Fremaux, J.,Dolain, C.,Goudreau, S.R.,Rochel, N.,Guichard, G.; Structural Basis for alpha-Helix Mimicry and Inhibition of Protein-Protein Interactions with Oligourea Foldamers.; Angew.Chem.Int.Ed.Engl., 60:2296-2303, 2021; PubMed: 32935897; DOI: 10.1002/anie.202008992

Experimental method

X-RAY DIFFRACTION (2 Å)