6XZI

Structure of zVDR LBD-calcitriol in complex with chimera 11

Summary for 6XZI

Entry DOI	10.2210/pdb6xzi/pdb
Descriptor	Vitamin D3 receptor A, ARG-HIS-LYS-ILE-LEU-URK-UIL-URL, 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, ... (5 entities in total)
Functional Keywords	nuclear receptor, foldamer, helix mimicry, protein-protein interaction, gene regulation
Biological source	Danio rerio (zebrafish) More
Total number of polymer chains	2
Total formula weight	35647.82
Authors	Buratto, J.,Belorusova, A.Y.,Rochel, N.,Guichard, G. (deposition date: 2020-02-04, release date: 2021-02-17, Last modification date: 2024-02-07)
Primary citation	Cussol, L.,Mauran-Ambrosino, L.,Buratto, J.,Belorusova, A.Y.,Neuville, M.,Osz, J.,Fribourg, S.,Fremaux, J.,Dolain, C.,Goudreau, S.R.,Rochel, N.,Guichard, G. Structural Basis for alpha-Helix Mimicry and Inhibition of Protein-Protein Interactions with Oligourea Foldamers. Angew.Chem.Int.Ed.Engl., 60:2296-2303, 2021 Cited by PubMed: 32935897 DOI: 10.1002/anie.202008992 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation