6XVP
Crystal structure of Neprilysin in complex with Sampatrilat.
Summary for 6XVP
| Entry DOI | 10.2210/pdb6xvp/pdb |
| Descriptor | Neprilysin, ZINC ION, Sampatrilat, ... (6 entities in total) |
| Functional Keywords | metallopeptidase, neural endopeptidase, sampatrilat, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 81639.99 |
| Authors | Cozier, G.E.,Acharya, K.R.,Sharma, U. (deposition date: 2020-01-22, release date: 2020-05-13, Last modification date: 2024-01-24) |
| Primary citation | Sharma, U.,Cozier, G.E.,Sturrock, E.D.,Acharya, K.R. Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin-Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme. J.Med.Chem., 63:5488-5500, 2020 Cited by PubMed: 32337993DOI: 10.1021/acs.jmedchem.0c00441 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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