6XSK

Cryo-EM Structure of Vaccine-Elicited Rhesus Antibody 789-203-3C12 in Complex with Stabilized SI06 (A/Solomon Islands/3/06) Influenza Hemagglutinin Trimer

6XSK の概要

• エントリーDOI: 10.2210/pdb6xsk/pdb
• EMDBエントリー: 22302
• 分子名称: 789-203-3C12 Fab Light Chain, 789-203-3C12 Fab Heavy Chain, Hemagglutinin HA1 chain, ... (7 entities in total)
• 機能のキーワード: hemagglutinin ectodomain, prefusion conformation, vaccine-elicited antibody, disulfide-stabilized trimer, immune system, immune system-viral protein complex, immune system/viral protein
• 由来する生物種: Macaca mulatta; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 415748.85

構造登録者

Cerutti, G.,Gorman, J.,Kwong, P.D.,Shapiro, L. (登録日: 2020-07-15, 公開日: 2021-07-21, 最終更新日: 2023-02-01)

• 主引用文献: Moin, S.M.,Boyington, J.C.,Boyoglu-Barnum, S.,Gillespie, R.A.,Cerutti, G.,Cheung, C.S.,Cagigi, A.,Gallagher, J.R.,Brand, J.,Prabhakaran, M.,Tsybovsky, Y.,Stephens, T.,Fisher, B.E.,Creanga, A.,Ataca, S.,Rawi, R.,Corbett, K.S.,Crank, M.C.,Karlsson Hedestam, G.B.,Gorman, J.,McDermott, A.B.,Harris, A.K.,Zhou, T.,Kwong, P.D.,Shapiro, L.,Mascola, J.R.,Graham, B.S.,Kanekiyo, M.; Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses.; Immunity, 55:2405-2418.e7, 2022; PubMed: 36356572; DOI: 10.1016/j.immuni.2022.10.015

実験手法

ELECTRON MICROSCOPY (3.85 Å)