6XQE
Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution
This is a non-PDB format compatible entry.
Summary for 6XQE
Entry DOI | 10.2210/pdb6xqe/pdb |
Descriptor | 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (60 entities in total) |
Functional Keywords | sarecycline; tetracycline; antibiotic; 70s ribosome; x-ray structure; inhibition of translation; decoding center; acne vulgaris, ribosome |
Biological source | Escherichia coli More |
Total number of polymer chains | 108 |
Total formula weight | 4469044.26 |
Authors | Batool, Z.,Lomakin, I.B.,Bunick, C.G.,Polikanov, Y.S. (deposition date: 2020-07-09, release date: 2020-08-05, Last modification date: 2023-11-15) |
Primary citation | Batool, Z.,Lomakin, I.B.,Polikanov, Y.S.,Bunick, C.G. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Proc.Natl.Acad.Sci.USA, 117:20530-20537, 2020 Cited by PubMed: 32817463DOI: 10.1073/pnas.2008671117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
Download full validation report