6XQE

Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution

これはPDB形式変換不可エントリーです。

6XQE の概要

• エントリーDOI: 10.2210/pdb6xqe/pdb
• 分子名称: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (60 entities in total)
• 機能のキーワード: sarecycline; tetracycline; antibiotic; 70s ribosome; x-ray structure; inhibition of translation; decoding center; acne vulgaris, ribosome
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 108
• 化学式量合計: 4469044.26

構造登録者

Batool, Z.,Lomakin, I.B.,Bunick, C.G.,Polikanov, Y.S. (登録日: 2020-07-09, 公開日: 2020-08-05, 最終更新日: 2023-11-15)

• 主引用文献: Batool, Z.,Lomakin, I.B.,Polikanov, Y.S.,Bunick, C.G.; Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome.; Proc.Natl.Acad.Sci.USA, 117:20530-20537, 2020; PubMed: 32817463; DOI: 10.1073/pnas.2008671117

実験手法

X-RAY DIFFRACTION (3 Å)