6XPP

Crystal structure of itaconate modified Mycobaterium tuberculosis isocitrate lyase

6XPP の概要

• エントリーDOI: 10.2210/pdb6xpp/pdb
• 分子名称: Isocitrate lyase, 2-methylidenebutanedioic acid, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: covalent modification, lyase
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 189252.40

構造登録者

Kwai, B.X.C.,Bashiri, G.,Leung, I.K.H. (登録日: 2020-07-08, 公開日: 2020-10-21, 最終更新日: 2023-10-18)

主引用文献

Kwai, B.X.C.,Collins, A.J.,Middleditch, M.J.,Sperry, J.,Bashiri, G.,Leung, I.K.H.
Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase.
Rsc Med Chem, 12:57-61, 2021

PubMed Abstract: Itaconate is a mammalian antimicrobial metabolite that inhibits the isocitrate lyases (ICLs) of . Herein, we report that ICLs form a covalent adduct with itaconate through their catalytic cysteine residue. These results reveal atomic details of itaconate inhibition and provide insights into the catalytic mechanism of ICLs.

PubMed: 34046597
DOI: 10.1039/d0md00301h

実験手法

X-RAY DIFFRACTION (1.55 Å)