6XON

DCN1 bound to inhibitor 9

6XON の概要

• エントリーDOI: 10.2210/pdb6xon/pdb
• 分子名称: Lysozyme DCN1-like protein 1 chimera, (2S)-N-[(2S)-2-cyclohexyl-2-({N-propanoyl-3-[6-(propan-2-yl)-1,3-benzothiazol-2-yl]-L-alanyl}amino)ethyl]-4-(dimethylamino)-2-methylbutanamide (3 entities in total)
• 機能のキーワード: inhibitor, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Enterobacteria phage T4; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44919.25

構造登録者

Stuckey, J.A. (登録日: 2020-07-07, 公開日: 2021-06-02, 最終更新日: 2023-10-18)

• 主引用文献: Zhou, H.,Lu, J.,Chinnaswamy, K.,Stuckey, J.A.,Liu, L.,McEachern, D.,Yang, C.Y.,Bernard, D.,Shen, H.,Rui, L.,Sun, Y.,Wang, S.; Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity.; Nat Commun, 12:2621-2621, 2021; PubMed: 33976147; DOI: 10.1038/s41467-021-22924-4

実験手法

X-RAY DIFFRACTION (2.8 Å)