6XLX

Crystal structure of cancer-associated G301D mutant of U2AF65 bound to AdML splice site

6XLX の概要

• エントリーDOI: 10.2210/pdb6xlx/pdb
• 分子名称: Splicing factor U2AF 65 kDa subunit, DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3') (3 entities in total)
• 機能のキーワード: protein-rna complex, rna splicing factor, rna recognition motif, polypyrimidine tract, rna binding protein-rna complex, rna binding protein, rna binding protein-splicing complex, rna binding protein/splicing
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24744.66

構造登録者

Maji, D.,Jenkins, J.L.,Kielkopf, C.L. (登録日: 2020-06-29, 公開日: 2020-10-07, 最終更新日: 2023-10-18)

• 主引用文献: Maji, D.,Glasser, E.,Henderson, S.,Galardi, J.,Pulvino, M.J.,Jenkins, J.L.,Kielkopf, C.L.; Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.; J.Biol.Chem., 295:17148-17157, 2020; PubMed: 33020180; DOI: 10.1074/jbc.RA120.015339

実験手法

X-RAY DIFFRACTION (1.7 Å)