6XL4

EGFR(T790M/V948R) in complex with AZD9291 and DDC4002

6XL4 の概要

• エントリーDOI: 10.2210/pdb6xl4/pdb
• 分子名称: Epidermal growth factor receptor, ~{N}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide, 10-benzyl-8-fluoro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one, ... (6 entities in total)
• 機能のキーワード: cancer, chemotherapy, kinase inhibitors, allosteric, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 152406.25

構造登録者

Heppner, D.E.,Beyett, T.S.,Eck, M.J. (登録日: 2020-06-28, 公開日: 2021-06-30, 最終更新日: 2023-10-18)

• 主引用文献: Beyett, T.S.,To, C.,Heppner, D.E.,Rana, J.K.,Schmoker, A.M.,Jang, J.,De Clercq, D.J.H.,Gomez, G.,Scott, D.A.,Gray, N.S.,Janne, P.A.,Eck, M.J.; Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.; Nat Commun, 13:2530-2530, 2022; PubMed: 35534503; DOI: 10.1038/s41467-022-30258-y

実験手法

X-RAY DIFFRACTION (2.06 Å)