6XKJ

Cryo-EM structure of CARD8-CARD filament

Summary for 6XKJ

• Entry DOI: 10.2210/pdb6xkj/pdb
• EMDB information: 22219 22220 22233
• Descriptor: Caspase recruitment domain-containing protein 8 (1 entity in total)
• Functional Keywords: filament, inflammasome, signaling, upa, fiind, card, nlrp1, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 16
• Total formula weight: 161653.97

Authors

Hollingsworth, L.R.,David, L.,Li, Y.,Sharif, H.,Fontana, P.,Fu, T.,Wu, H. (deposition date: 2020-06-26, release date: 2020-11-25, Last modification date: 2024-03-06)

• Primary citation: Robert Hollingsworth, L.,David, L.,Li, Y.,Griswold, A.R.,Ruan, J.,Sharif, H.,Fontana, P.,Orth-He, E.L.,Fu, T.M.,Bachovchin, D.A.,Wu, H.; Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.; Nat Commun, 12:189-189, 2021; PubMed: 33420033; DOI: 10.1038/s41467-020-20320-y

Experimental method

ELECTRON MICROSCOPY (3.54 Å)