6XKG

Crystal structure of 3-O-Sulfotransferase isoform 3 in complex with 8mer oligosaccharide with 6S sulfation

Summary for 6XKG

• Entry DOI: 10.2210/pdb6xkg/pdb
• Descriptor: Heparan sulfate glucosamine 3-O-sulfotransferase 3A1, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, ... (8 entities in total)
• Functional Keywords: sulfotransferase, enzyme, paps, heparan sulfate, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 67845.11

Authors

Pedersen, L.C.,Liu, J.,Wander, R. (deposition date: 2020-06-26, release date: 2021-06-23, Last modification date: 2023-10-18)

• Primary citation: Wander, R.,Kaminski, A.M.,Xu, Y.,Pagadala, V.,Krahn, J.M.,Pham, T.Q.,Liu, J.,Pedersen, L.C.; Deciphering the substrate recognition mechanisms of the heparan sulfate 3- O -sulfotransferase-3.; Rsc Chem Biol, 2:1239-1248, 2021; PubMed: 34458837; DOI: 10.1039/d1cb00079a

Experimental method

X-RAY DIFFRACTION (1.55 Å)