6XKG

Crystal structure of 3-O-Sulfotransferase isoform 3 in complex with 8mer oligosaccharide with 6S sulfation

6XKG の概要

• エントリーDOI: 10.2210/pdb6xkg/pdb
• 分子名称: Heparan sulfate glucosamine 3-O-sulfotransferase 3A1, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, ... (8 entities in total)
• 機能のキーワード: sulfotransferase, enzyme, paps, heparan sulfate, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67845.11

構造登録者

Pedersen, L.C.,Liu, J.,Wander, R. (登録日: 2020-06-26, 公開日: 2021-06-23, 最終更新日: 2023-10-18)

• 主引用文献: Wander, R.,Kaminski, A.M.,Xu, Y.,Pagadala, V.,Krahn, J.M.,Pham, T.Q.,Liu, J.,Pedersen, L.C.; Deciphering the substrate recognition mechanisms of the heparan sulfate 3- O -sulfotransferase-3.; Rsc Chem Biol, 2:1239-1248, 2021; PubMed: 34458837; DOI: 10.1039/d1cb00079a

実験手法

X-RAY DIFFRACTION (1.55 Å)