6XH3

Co-crystal structure of HIV-1 TAR RNA in complex with lab-evolved RRM TBP6.3

Summary for 6XH3

• Entry DOI: 10.2210/pdb6xh3/pdb
• Descriptor: TAR BINDING PROTEIN TBP 6.3, TRANS-ACTIVATION RESPONSE ELEMENT (3 entities in total)
• Functional Keywords: protein-rna complex, tar rna, lab-evolved protein, arginine fork, beta hairpin, major-groove readout, base triple, u1a, hiv-1, trans- activation, rna recognition motif, rrm, rna binding protein-rna complex, rna binding protein, rna binding protein/rna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 18886.07

Authors

Chavali, S.S.,Jenkins, J.L.,Wedekind, J.E. (deposition date: 2020-06-18, release date: 2020-10-14, Last modification date: 2024-03-06)

• Primary citation: Chavali, S.S.,Mali, S.M.,Jenkins, J.L.,Fasan, R.,Wedekind, J.E.; Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors.; J.Biol.Chem., 295:16470-16486, 2020; PubMed: 33051202; DOI: 10.1074/jbc.RA120.015444

Experimental method

X-RAY DIFFRACTION (2.353 Å)