6XH2

Co-crystal structure of HIV-1 TAR RNA in complex with lab-evolved RRM 6.6

6XH2 の概要

• エントリーDOI: 10.2210/pdb6xh2/pdb
• 分子名称: TAR-BINDING PROTEIN 6.6, TRANS-ACTIVATION RESPONSE ELEMENT (3 entities in total)
• 機能のキーワード: protein-rna complex, tar rna, lab-evolved protein, arginine fork, beta hairpin, major-groove readout, base triple, u1a, hiv-1, trans- activation, rna recognition motif, rrm, rna binding protein-rna complex, rna binding protein, rna binding protein/rna
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 19351.61

構造登録者

Chavali, S.S.,Jenkins, J.L.,Wedekind, J.E. (登録日: 2020-06-18, 公開日: 2020-10-14, 最終更新日: 2023-10-18)

• 主引用文献: Chavali, S.S.,Mali, S.M.,Jenkins, J.L.,Fasan, R.,Wedekind, J.E.; Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors.; J.Biol.Chem., 295:16470-16486, 2020; PubMed: 33051202; DOI: 10.1074/jbc.RA120.015444

実験手法

X-RAY DIFFRACTION (1.71 Å)