6XF6

Cryo-EM structure of a biotinylated SARS-CoV-2 spike probe in the prefusion state (1 RBD up)

6XF6 の概要

• エントリーDOI: 10.2210/pdb6xf6/pdb
• 関連するPDBエントリー: 6XF5
• EMDBエントリー: 22161 22162
• 分子名称: Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: fusion protein, molecular probe, spike glycoprotein, covid-19, rbd, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 429004.98

構造登録者

Cerutti, G.,Gorman, J.,Kwong, P.D.,Shapiro, L. (登録日: 2020-06-15, 公開日: 2020-09-02, 最終更新日: 2020-12-02)

• 主引用文献: Zhou, T.,Teng, I.T.,Olia, A.S.,Cerutti, G.,Gorman, J.,Nazzari, A.,Shi, W.,Tsybovsky, Y.,Wang, L.,Wang, S.,Zhang, B.,Zhang, Y.,Katsamba, P.S.,Petrova, Y.,Banach, B.B.,Fahad, A.S.,Liu, L.,Acevedo, S.N.L.,Madan, B.,de Souza, M.O.,Pan, X.,Wang, P.,Wolfe, J.R.,Yin, M.,Ho, D.D.,Phung, E.,DiPiazza, A.,Chang, L.,Abiona, O.,Corbett, K.S.,DeKosky, B.J.,Graham, B.S.,Mascola, J.R.,Misasi, J.,Ruckwardt, T.,Sullivan, N.J.,Shapiro, L.,Kwong, P.D.; Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes.; SSRN, :3639618-3639618, 2020; PubMed: 32742241; DOI: 10.2139/ssrn.3639618

実験手法

ELECTRON MICROSCOPY (4 Å)