6XEZ

Structure of SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC

Summary for 6XEZ

• Entry DOI: 10.2210/pdb6xez/pdb
• EMDB information: 22160 22270 22271
• Descriptor: RNA-directed RNA polymerase, CHAPSO, ALUMINUM FLUORIDE, ... (11 entities in total)
• Functional Keywords: rna-dependent rna polymerase, viral replication-transcription complex, transcription, viral proteins, transferase-hydrolase-rna complex, transferase/hydrolase/rna
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 8
• Total formula weight: 327962.35

Authors

Chen, J.,Malone, B.,Llewellyn, E.C.,Campbell, E.A.,Darst, S.A. (deposition date: 2020-06-14, release date: 2020-07-29, Last modification date: 2024-03-06)

• Primary citation: Chen, J.,Malone, B.,Llewellyn, E.,Grasso, M.,Shelton, P.M.M.,Olinares, P.D.B.,Maruthi, K.,Eng, E.T.,Vatandaslar, H.,Chait, B.T.,Kapoor, T.M.,Darst, S.A.,Campbell, E.A.; Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex.; Cell, 182:1560-1573.e13, 2020; PubMed: 32783916; DOI: 10.1016/j.cell.2020.07.033

Experimental method

ELECTRON MICROSCOPY (3.5 Å)