6XEF
Crystal structure of the PTP1B YopH WPD loop Chimera 4 bound to vanadate
Summary for 6XEF
Entry DOI | 10.2210/pdb6xef/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | ptp1b, tyrosine phosphatase, wpd loop, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 37781.43 |
Authors | Olsen, K.J.,Shen, R.,Johnson, S.J.,Hengge, A.C. (deposition date: 2020-06-12, release date: 2021-12-15, Last modification date: 2023-10-25) |
Primary citation | Shen, R.,Crean, R.M.,Olsen, K.J.,Corbella, M.,Calixto, A.R.,Richan, T.,Brandao, T.A.S.,Berry, R.D.,Tolman, A.,Loria, J.P.,Johnson, S.J.,Kamerlin, S.C.L.,Hengge, A.C. Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13:13524-13540, 2022 Cited by PubMed: 36507179DOI: 10.1039/d2sc04135a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.048 Å) |
Structure validation
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