6XEB
STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH KETONE INHIBITOR (COMPOUND E)
Summary for 6XEB
Entry DOI | 10.2210/pdb6xeb/pdb |
Descriptor | Histone deacetylase 2, ZINC ION, SULFATE ION, ... (7 entities in total) |
Functional Keywords | histone deacetylase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 132698.83 |
Authors | Klein, D.J.,Clausen, D. (deposition date: 2020-06-12, release date: 2020-08-12, Last modification date: 2024-03-06) |
Primary citation | Clausen, D.J.,Liu, J.,Yu, W.,Duffy, J.L.,Chung, C.C.,Myers, R.W.,Klein, D.J.,Fells, J.,Holloway, K.,Wu, J.,Wu, G.,Howell, B.J.,Barnard, R.J.O.,Kozlowski, J. Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir. Bioorg.Med.Chem.Lett., 30:127367-127367, 2020 Cited by PubMed: 32738976DOI: 10.1016/j.bmcl.2020.127367 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
Download full validation report