6XD9

Carbonmonoxy hemoglobin in complex with the antisickling agent 2-hydroxy-6-((6-(hydroxymethyl)pyridin-2-yl)methoxy)benzaldehyde (VZHE039)

Summary for 6XD9

Entry DOI	10.2210/pdb6xd9/pdb
Descriptor	Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (6 entities in total)
Functional Keywords	hemoglobin, aromatic aldehyde, antisickling, allosteric effector, oxygen transport
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	65149.64
Authors	Pagare, P.P.,Safo, M.K.,Musayev, F.N. (deposition date: 2020-06-10, release date: 2020-12-23, Last modification date: 2023-10-18)
Primary citation	Abdulmalik, O.,Pagare, P.P.,Huang, B.,Xu, G.G.,Ghatge, M.S.,Xu, X.,Chen, Q.,Anabaraonye, N.,Musayev, F.N.,Omar, A.M.,Venitz, J.,Zhang, Y.,Safo, M.K. VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions. Sci Rep, 10:20277-20277, 2020 Cited by PubMed: 33219275 DOI: 10.1038/s41598-020-77171-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation