6XCM

Structure of the SARS-CoV-2 spike glycoprotein in complex with the C105 neutralizing antibody Fab fragment (state 1)

6XCM の概要

• エントリーDOI: 10.2210/pdb6xcm/pdb
• EMDBエントリー: 22127 22128
• 分子名称: Spike glycoprotein, C105 Fab Heavy Chain, C105 Fab Light Chain, ... (8 entities in total)
• 機能のキーワード: sars-cov-2, spike glycoprotein, covid-19, monoclonal neutralizing antibody, fabs, nsempem, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 7
• 化学式量合計: 527029.15

構造登録者

Barnes, C.O.,Bjorkman, P.J. (登録日: 2020-06-08, 公開日: 2020-07-01, 最終更新日: 2020-09-02)

• 主引用文献: Barnes, C.O.,West Jr., A.P.,Huey-Tubman, K.E.,Hoffmann, M.A.G.,Sharaf, N.G.,Hoffman, P.R.,Koranda, N.,Gristick, H.B.,Gaebler, C.,Muecksch, F.,Lorenzi, J.C.C.,Finkin, S.,Hagglof, T.,Hurley, A.,Millard, K.G.,Weisblum, Y.,Schmidt, F.,Hatziioannou, T.,Bieniasz, P.D.,Caskey, M.,Robbiani, D.F.,Nussenzweig, M.C.,Bjorkman, P.J.; Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies.; Cell, 182:828-, 2020; PubMed: 32645326; DOI: 10.1016/j.cell.2020.06.025

実験手法

ELECTRON MICROSCOPY (3.42 Å)