6XCJ

Crystal Structure of DH650 Fab from a Rhesus Macaque in Complex with HIV-1 gp120 Core

6XCJ の概要

• エントリーDOI: 10.2210/pdb6xcj/pdb
• 分子名称: Envelope Glycoprotein gp120, DH650 Fab Heavy Chain, DH650 Fab Light Chain, ... (5 entities in total)
• 機能のキーワード: hiv, fab, antibody, neutralizing, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 90134.12

構造登録者

Raymond, D.D.,Chug, H.,Harrison, S.C. (登録日: 2020-06-08, 公開日: 2020-12-02, 最終更新日: 2023-10-18)

• 主引用文献: Roark, R.S.,Li, H.,Williams, W.B.,Chug, H.,Mason, R.D.,Gorman, J.,Wang, S.,Lee, F.H.,Rando, J.,Bonsignori, M.,Hwang, K.K.,Saunders, K.O.,Wiehe, K.,Moody, M.A.,Hraber, P.T.,Wagh, K.,Giorgi, E.E.,Russell, R.M.,Bibollet-Ruche, F.,Liu, W.,Connell, J.,Smith, A.G.,DeVoto, J.,Murphy, A.I.,Smith, J.,Ding, W.,Zhao, C.,Chohan, N.,Okumura, M.,Rosario, C.,Ding, Y.,Lindemuth, E.,Bauer, A.M.,Bar, K.J.,Ambrozak, D.,Chao, C.W.,Chuang, G.Y.,Geng, H.,Lin, B.C.,Louder, M.K.,Nguyen, R.,Zhang, B.,Lewis, M.G.,Raymond, D.D.,Doria-Rose, N.A.,Schramm, C.A.,Douek, D.C.,Roederer, M.,Kepler, T.B.,Kelsoe, G.,Mascola, J.R.,Kwong, P.D.,Korber, B.T.,Harrison, S.C.,Haynes, B.F.,Hahn, B.H.,Shaw, G.M.; Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.; Science, 371:-, 2021; PubMed: 33214287; DOI: 10.1126/science.abd2638

実験手法

X-RAY DIFFRACTION (2.8 Å)