6XAR

Structure of CBL tyrosine kinase binding domain (TKBD) with C-terminal tail of Src-like kinase protein 2 (SLAP2)

Summary for 6XAR

Entry DOI	10.2210/pdb6xar/pdb
Descriptor	E3 ubiquitin-protein ligase CBL, Src-like-adapter 2, CALCIUM ION, ... (4 entities in total)
Functional Keywords	adaptor, e3 ubiquitin ligase, activation, complex, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	81880.28
Authors	Wybenga-Groot, L.E.,McGlade, C.J. (deposition date: 2020-06-04, release date: 2021-03-03, Last modification date: 2023-10-18)
Primary citation	Wybenga-Groot, L.E.,Tench, A.J.,Simpson, C.D.,Germain, J.S.,Raught, B.,Moran, M.F.,McGlade, C.J. SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function. J.Mol.Biol., 433:166880-166880, 2021 Cited by PubMed: 33617900 DOI: 10.1016/j.jmb.2021.166880 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.501 Å)

Structure validation