6XA2

Structure of the tirandamycin C-bound P450 monooxygenase TamI

6XA2 の概要

• エントリーDOI: 10.2210/pdb6xa2/pdb
• 分子名称: TamI, PROTOPORPHYRIN IX CONTAINING FE, (3E)-3-{(2E,4E,6R)-1-hydroxy-4-methyl-6-[(1R,3R,4S,5R)-1,4,8-trimethyl-2,9-dioxabicyclo[3.3.1]non-7-en-3-yl]hepta-2,4-dien-1-ylidene}-2H-pyrrole-2,4(3H)-dione, ... (4 entities in total)
• 機能のキーワード: p450, monooxygenase, oxidoreductase
• 由来する生物種: Streptomyces sp. 307-9
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 373712.21

構造登録者

Newmister, S.A.,Srivastava, K.R.,Espinoza, R.V.,Haatveit, K.C.,Khatri, Y.,Martini, R.M.,Garcia-Borras, M.,Podust, L.M.,Houk, K.N.,Sherman, D.H. (登録日: 2020-06-03, 公開日: 2021-06-09, 最終更新日: 2024-04-03)

• 主引用文献: Newmister, S.A.,Srivastava, K.R.,Espinoza, R.V.,Haatveit, K.C.,Khatri, Y.,Martini, R.M.,Garcia-Borras, M.,Podust, L.M.,Houk, K.N.,Sherman, D.H.; Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway.; Acs Catalysis, 10:13445-13454, 2020; PubMed: 33569241; DOI: 10.1021/acscatal.0c03248

実験手法

X-RAY DIFFRACTION (2.64 Å)