6X7B

BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212P

6X7B の概要

• エントリーDOI: 10.2210/pdb6x7b/pdb
• 分子名称: Bromodomain-containing protein 4, 7-[7-oxo-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide (3 entities in total)
• 機能のキーワード: brd4, pi3k, cdk4/6, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32717.62

構造登録者

Vann, K.R.,Kutateladze, T.G. (登録日: 2020-05-29, 公開日: 2020-08-05, 最終更新日: 2023-10-18)

• 主引用文献: Vann, K.R.,Pal, D.,Morales, G.A.,Burgoyne, A.M.,Durden, D.L.,Kutateladze, T.G.; Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets.; Sci Rep, 10:12027-12027, 2020; PubMed: 32694708; DOI: 10.1038/s41598-020-68964-6

実験手法

X-RAY DIFFRACTION (1.951 Å)