6X5P

Discovery of Hydroxy Pyrimidine Factor IXa Inhibitors

6X5P の概要

• エントリーDOI: 10.2210/pdb6x5p/pdb
• 関連するPDBエントリー: 6X5J 6X5L
• 分子名称: Coagulation factor IX, 3-chloro-4-{[5-hydroxy-6-(4-methylphenyl)pyrimidin-4-yl]amino}benzene-1-carboximidamide, CITRIC ACID, ... (6 entities in total)
• 機能のキーワード: serine protease, zymogen, hydrolase, glycoprotein, hydroxylation, phosphoprotein, sulfation, hemostasis, hemophilia, xase-like variant, communication channel, gamma-carboxyglutamic acid, egf-like domain, disease mutation, blood clotting
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34253.00

構造登録者

Jayne, C.L.,Andreani, T.,Chan, T.,Chelliah, M.V.,Clasby, M.C.,Dwyer, M.,Eagen, K.A.,Fried, S.,Greenlee, W.J.,Guo, Z.,Hawes, B.,Hruza, A.,Ingram, R.,Keertikar, K.M.,Neelamkavil, S.,Reichert, P.,Xia, Y.,Chackalamannil, S. (登録日: 2020-05-26, 公開日: 2020-06-24)

• 主引用文献: Jayne, C.L.,Andreani, T.,Chan, T.Y.,Chelliah, M.V.,Clasby, M.C.,Dwyer, M.,Eagen, K.A.,Fried, S.,Greenlee, W.J.,Guo, Z.,Hawes, B.,Hruza, A.,Ingram, R.,Keertikar, K.M.,Neelamkavil, S.,Reichert, P.,Xia, Y.,Chackalamannil, S.; Discovery of hydroxy pyrimidine Factor IXa inhibitors.; Bioorg.Med.Chem.Lett., 30:127279-127279, 2020; PubMed: 32527459; DOI: 10.1016/j.bmcl.2020.127279

実験手法

X-RAY DIFFRACTION (1.997 Å)