6X5M

Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail, in complex with Fab-BL-3,6.

6X5M の概要

• エントリーDOI: 10.2210/pdb6x5m/pdb
• 分子名称: Light chain Fab BL-3 6, Heavy chain Fab Bl-3 6, ggPAN RNA (39-MER), ... (6 entities in total)
• 機能のキーワード: viral encoded rna, rna therapeutics, structure-function studies, small molecules binding, pan triplex, ggene, ggca9, rna, immune system-rna complex, immune system/rna
• 由来する生物種: Mus musculus; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 152041.16

構造登録者

Swain, M.,Li, M.,Wlodawer, A.,Le Grice, S.F.J. (登録日: 2020-05-26, 公開日: 2020-06-24, 最終更新日: 2023-10-18)

• 主引用文献: Swain, M.,Ageeli, A.A.,Kasprzak, W.K.,Li, M.,Miller, J.T.,Sztuba-Solinska, J.,Schneekloth, J.S.,Koirala, D.,Piccirili, J.,Fraboni, A.J.,Murelli, R.P.,Wlodawer, A.,Shapiro, B.A.,Baird, N.,Le Grice, S.F.J.; Dynamic bulge nucleotides in the KSHV PAN ENE triple helix provide a unique binding platform for small molecule ligands.; Nucleic Acids Res., 49:13179-13193, 2021; PubMed: 34871450; DOI: 10.1093/nar/gkab1170

実験手法

X-RAY DIFFRACTION (2.5 Å)