6X5J
Discovery of Hydroxy Pyrimidine Factor IXa Inhibitors
Summary for 6X5J
Entry DOI | 10.2210/pdb6x5j/pdb |
Related | 6X5L 6X5P |
Descriptor | Coagulation factor IX, GLYCEROL, 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE, ... (7 entities in total) |
Functional Keywords | serine protease, zymogen, hydrolase, glycoprotein, hydroxylation, phosphoprotein, sulfation, hemostasis, hemophilia, xase-like variant, communication channel, gamma-carboxyglutamic acid, egf-like domain, disease mutation, blood clotting |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 34326.63 |
Authors | Jayne, C.L.,Andreani, T.,Chan, T.,Chelliah, M.V.,Clasby, M.C.,Dwyer, M.,Eagen, K.A.,Fried, S.,Greenlee, W.J.,Guo, Z.,Hawes, B.,Hruza, A.,Ingram, R.,Keertikar, K.M.,Neelamkavil, S.,Reichert, P.,Xia, Y.,Chackalamannil, S. (deposition date: 2020-05-26, release date: 2020-06-24) |
Primary citation | Jayne, C.L.,Andreani, T.,Chan, T.Y.,Chelliah, M.V.,Clasby, M.C.,Dwyer, M.,Eagen, K.A.,Fried, S.,Greenlee, W.J.,Guo, Z.,Hawes, B.,Hruza, A.,Ingram, R.,Keertikar, K.M.,Neelamkavil, S.,Reichert, P.,Xia, Y.,Chackalamannil, S. Discovery of hydroxy pyrimidine Factor IXa inhibitors. Bioorg.Med.Chem.Lett., 30:127279-127279, 2020 Cited by PubMed: 32527459DOI: 10.1016/j.bmcl.2020.127279 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.513 Å) |
Structure validation
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