6X1F

Tubulin-RB3_SLD-TTL in complex with compound 5m

6X1F の概要

• エントリーDOI: 10.2210/pdb6x1f/pdb
• 分子名称: Tubulin alpha-1B chain, 7-methoxy-4-(2-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• 機能のキーワード: microtubule inhibitor, colchicine, cell cycle, cancer, cell cycle-inhibitor complex, cell cycle/inhibitor
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 264987.17

構造登録者

White, S.W.,Yun, M. (登録日: 2020-05-18, 公開日: 2021-09-22, 最終更新日: 2023-10-18)

• 主引用文献: Banerjee, S.,Mahmud, F.,Deng, S.,Ma, L.,Yun, M.K.,Fakayode, S.O.,Arnst, K.E.,Yang, L.,Chen, H.,Wu, Z.,Lukka, P.B.,Parmar, K.,Meibohm, B.,White, S.W.,Wang, Y.,Li, W.,Miller, D.D.; X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.; J.Med.Chem., 64:13072-13095, 2021; PubMed: 34406768; DOI: 10.1021/acs.jmedchem.1c01202

実験手法

X-RAY DIFFRACTION (2.7 Å)