6WY1

Crystal structure of an engineered thermostable dengue virus 2 envelope protein dimer

Summary for 6WY1

Entry DOI	10.2210/pdb6wy1/pdb
Descriptor	Dengue 2 soluble recombinant envelope, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
Functional Keywords	dengue virus, envelope protein, thermostable, computational protein design, protein engineering, viral protein
Biological source	Dengue virus 2
Total number of polymer chains	1
Total formula weight	45915.53
Authors	Kudlacek, S.T.,Lakshmanane, P.,Kuhlman, B. (deposition date: 2020-05-12, release date: 2021-11-10, Last modification date: 2023-10-18)
Primary citation	Kudlacek, S.T.,Metz, S.,Thiono, D.,Payne, A.M.,Phan, T.T.N.,Tian, S.,Forsberg, L.J.,Maguire, J.,Seim, I.,Zhang, S.,Tripathy, A.,Harrison, J.,Nicely, N.I.,Soman, S.,McCracken, M.K.,Gromowski, G.D.,Jarman, R.G.,Premkumar, L.,de Silva, A.M.,Kuhlman, B. Designed, highly expressing, thermostable dengue virus 2 envelope protein dimers elicit quaternary epitope antibodies. Sci Adv, 7:eabg4084-eabg4084, 2021 Cited by PubMed: 34652943 DOI: 10.1126/sciadv.abg4084 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.42 Å)

Structure validation