6WX2
Vaccine-elicited mouse FP-targeting neutralizing antibody vFP16.02 with F60P mutation on light chain in complex with HIV fusion peptide (residue 512-519)
Summary for 6WX2
Entry DOI | 10.2210/pdb6wx2/pdb |
Descriptor | vFP16.02 antibody heavy chain, vFP16.02 antibody light chain, fusion peptide, ... (4 entities in total) |
Functional Keywords | hiv, fusion peptide, antibody, immune system-viral protein complex, immune system/viral protein |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 95788.78 |
Authors | Xu, K.,Wang, Y.,Kwong, P.D. (deposition date: 2020-05-09, release date: 2021-03-17, Last modification date: 2023-10-18) |
Primary citation | Madan, B.,Zhang, B.,Xu, K.,Chao, C.W.,O'Dell, S.,Wolfe, J.R.,Chuang, G.Y.,Fahad, A.S.,Geng, H.,Kong, R.,Louder, M.K.,Nguyen, T.D.,Rawi, R.,Schon, A.,Sheng, Z.,Nimrania, R.,Wang, Y.,Zhou, T.,Lin, B.C.,Doria-Rose, N.A.,Shapiro, L.,Kwong, P.D.,DeKosky, B.J. Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 33649208DOI: 10.1073/pnas.2011653118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.39 Å) |
Structure validation
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