6WW0

Human steroidogenic cytochrome P450 17A1 with 3-keto-5alpha-abiraterone analog

6WW0 の概要

• エントリーDOI: 10.2210/pdb6ww0/pdb
• 分子名称: Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, (5alpha,8alpha)-17-(pyridin-3-yl)androst-16-en-3-one, ... (5 entities in total)
• 機能のキーワード: cytochrome p450, p450, 17a1, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 226895.45

構造登録者

Petrunak, E.M.,Bart, A.G.,Scott, E.E. (登録日: 2020-05-07, 公開日: 2021-05-26, 最終更新日: 2023-10-18)

• 主引用文献: Petrunak, E.M.,Bart, A.G.,Peng, H.M.,Auchus, R.J.,Scott, E.E.; Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site.; J.Biol.Chem., 299:102999-102999, 2023; PubMed: 36773804; DOI: 10.1016/j.jbc.2023.102999

実験手法

X-RAY DIFFRACTION (2.01 Å)