6WVX
Crystal structure of the first bromodomain of human BRD4 with benzodiazepine inhibitor
6WVX の概要
エントリーDOI | 10.2210/pdb6wvx/pdb |
分子名称 | Bromodomain-containing protein 4, 6'-(4-chlorophenyl)-1'-methyl-8'-(1-methyl-1H-pyrazol-4-yl)spiro[cyclopropane-1,4'-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine] (3 entities in total) |
機能のキーワード | inhibitor, bromodomain, brd4, benzodiazepine, gene regulation, gene regulation-inhibitor complex, gene regulation/inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 31142.64 |
構造登録者 | |
主引用文献 | Eron, S.J.,Huang, H.,Agafonov, R.V.,Fitzgerald, M.E.,Patel, J.,Michael, R.E.,Lee, T.D.,Hart, A.A.,Shaulsky, J.,Nasveschuk, C.G.,Phillips, A.J.,Fisher, S.L.,Good, A. Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen-Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design. Acs Chem.Biol., 16:2228-2243, 2021 Cited by PubMed: 34582690DOI: 10.1021/acschembio.1c00376 主引用文献が同じPDBエントリー |
実験手法 |
構造検証レポート
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